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曾锐/姚颖/徐钢等Cell子刊:干酪乳杆菌Zhang缓解肾病

发布日期:2021-07-26
  1.在双肾缺血再灌注(I/R)等急性肾损伤(AKI)小鼠模型中,预防性补充干酪乳杆菌Zhang(LcZ)能减轻AKI和之后的慢性肾纤维化,效果优于嗜酸乳杆菌;

  2.肠道菌群失调促进肾脏炎症和纤维化,补充LcZ能改善I/R引起的肠道菌群失调、肠屏障损伤和炎症,升高有益代谢物短链脂肪酸和烟酰胺,从而减少肾脏巨噬细胞和肾小管上皮细胞的炎症反应,发挥肾保护作用;

  3.在纳入62名3-5期慢性肾病患者的1期安慰剂对照试验中,补充LcZ能减缓肾功能衰退,且安全性好。

  主编推荐语

  mildbreeze

  肠道菌群可通过其代谢产物等机制影响肾脏疾病的发生发展,益生菌干预或可用于肾脏疾病的预防和治疗。Cell Metabolism最新发表了来自华中科技大学同济医学院附属同济医院曾锐教授、姚颖教授、徐钢教授带领团队的研究成果,内蒙古农业大学张和平教授参与并署名。该研究结合小鼠动物实验和临床试验,揭示了肠道菌群失调和益生菌干预在急性肾损伤和慢性肾病中的作用和机制,表明补充干酪乳杆菌Zhang能通过改善肠道菌群、增加有益代谢物(如短链脂肪酸和烟酰胺),来减轻肾损伤、减缓肾功能衰退。相关成果具有临床应用前景,值得专业人士关注!

Cell Metabolism
[IF:27.287]
The probiotic L. casei Zhang slows the progression of acute and chronic kidney disease

益生菌干酪乳杆菌Zhang减缓急性和慢性肾病的进展

10.1016/j.cmet.2021.06.014

07-15, Article

Abstract:

The relationship between gut microbial dysbiosis and acute or chronic kidney disease (CKD) is still unclear. Here, we show that oral administration of the probiotic Lactobacillus casei Zhang (L. casei Zhang) corrected bilateral renal ischemia-reperfusion (I/R)-induced gut microbial dysbiosis, alleviated kidney injury, and delayed its progression to CKD in mice. L. casei Zhang elevated the levels of short-chain fatty acids (SCFAs) and nicotinamide in the serum and kidney, resulting in reduced renal inflammation and damage to renal tubular epithelial cells. We also performed a 1-year phase 1 placebo-controlled study of oral L. casei Zhang use (Chinese clinical trial registry, ChiCTR-INR-17013952), which was well tolerated and slowed the decline of kidney function in individuals with stage 3–5 CKD. These results show that oral administration of L. casei Zhang, by altering SCFAs and nicotinamide metabolism, is a potential therapy to mitigate kidney injury and slow the progression of renal decline.

First Authors:
Han Zhu,Chujin Cao

Correspondence Authors:
Gang Xu,Ying Yao,Rui Zeng

All Authors:
Han Zhu,Chujin Cao,Zhongcai Wu,Heping Zhang,Zhihong Sun,Meng Wang,Huzi Xu,Zhi Zhao,Yuxi Wang,Guangchang Pei,Qian Yang,Fengming Zhu,Juan Yang,Xuan Deng,Yu Hong,Yinzheng Li,Jie Sun,Fan Zhu,Mengxia Shi,Kun Qian,Ting Ye,Xuezhi Zuo,Fenfei Zhao,Jing Guo,Gang Xu,Ying Yao,Rui Zeng

 来源:网络


 
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